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1

Overall mechanism behind matrix sustained release (SR) tablets prepared with hydroxypropyl methylcellulose 2910

Koichiro Tahara, Ken Yamamoto, Toshiaki Nishihata

Journal:

Journal of Controlled Release

Année:

1995

Langue:

english

Fichier:

PDF, 602 KB

english, 1995

2

Enhancement of rectal absorption of drugs by adjuvants

Toshiaki Nishihata, J. Howard Rytting, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1980

Langue:

english

Fichier:

PDF, 240 KB

english, 1980

3

Effects of salicylate on rectal absorption of theophylline

Toshiaki Nishihata, J. Howard Rytting, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1981

Langue:

english

Fichier:

PDF, 523 KB

english, 1981

4

Effect of salicylate on the rectal absorption of lidocaine, levodopa, and cefmetazole in rats

Toshiaki Nishihata, J. Howard Rytting, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1982

Langue:

english

Fichier:

PDF, 406 KB

english, 1982

5

Enhanced rectal absorption of theophylline, lidocaine, cefmetazole, and levodopa by several adjuvants

Toshiaki Nishihata, J. Howard Rytting, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1982

Langue:

english

Fichier:

PDF, 376 KB

english, 1982

6

Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits

Toshiaki Nishihata, Suni Kim, Shigeyoshi Morishita, Akira Kamada, Noboru Yata, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1983

Langue:

english

Fichier:

PDF, 553 KB

english, 1983

7

Enhanced rectal absorption of cefmetazole and cefoxitin in the presence of epinephrine metabolites in rats and a high-performance liquid chromatographic assay for cephamycin antibiotics

Toshiaki Nishihata, Hidekuni Takahagi, Midori Yamamoto, Hisao Tomida, J. Howard Rytting, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1984

Langue:

english

Fichier:

PDF, 382 KB

english, 1984

8

The effects of salicylate on the rectal absorption of phenylalanine and some peptides, and the effects of these peptides on the rectal absorption of cefoxitin and cefmetazole

Toshiaki Nishihata, Chia-Shun Lee, Midori Yamamoto, J. Howard Rytting, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1984

Langue:

english

Fichier:

PDF, 290 KB

english, 1984

9

Possible mechanism behind the adjuvant action of phosphate derivatives on rectal absorption of cefoxitin in rats and dogs

Toshiaki Nishihata, Chia-Shun Lee, Ba Thu Nghiem, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Année:

1984

Langue:

english

Fichier:

PDF, 377 KB

english, 1984

10

Combined effect of alcohol and urea on the in vitro transport of indomethacin across rat dorsal skin

Toshiaki Nishihata, J. Howard Rytting, Akira Kamada, Koichi Matsumoto, Koichi Takahashi

Journal:

Journal of Pharmaceutical Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 318 KB

english, 1990

11

A Method to Predict the Percutaneous Permeability of Various Compounds: Shed Snake Skin as a Model Membrane

Tomoo Itoh, Ravi Magavi, Roger L. Casady, Toshiaki Nishihata, J. Howard Rytting

Journal:

Pharmaceutical Research

Année:

1990

Fichier:

PDF, 815 KB

1990

12

Use of Shed Snake Skin as a Model Membrane forin VitroPercutaneous Penetration Studies: Comparison with Human Skin

Tomoo Itoh, Jun Xia, Ravi Magavi, Toshiaki Nishihata, J. Howard Rytting

Journal:

Pharmaceutical Research

Année:

1990

Fichier:

PDF, 1.14 MB

1990

13

Study of the Interaction Between β-Cyclodextrin and Chlorhexidine

Hong Qi, Toshiaki Nishihata, J. Howard Rytting

Journal:

Pharmaceutical Research

Année:

1994

Fichier:

PDF, 606 KB

1994

14

The effects of complexation with hydrogenated phospholipid on the transport of salicylic acid, diclofenac and indomethacin across snake stratum corneum

Shobha N. Bhattachar, J.Howard Rytting, Itoh Tomoo, Nishihata Toshiaki

Journal:

International Journal of Pharmaceutics

Année:

1992

Langue:

english

Fichier:

PDF, 611 KB

english, 1992

15

Characteristics of intestinal absorption of adinazolam and in vivo evaluation of oral sustained release tablets of adinazolam in beagle dogs

Koichiro Tahara, Masaaki Mikawa, Shigeharu Yokohama, Toshiaki Nishihata

Journal:

International Journal of Pharmaceutics

Année:

1993

Langue:

english

Fichier:

PDF, 666 KB

english, 1993

16

Bioavailability of itazigrel in dogs after oral administration of soft elastic capsules

Yamamoto Ken, Yokohama Shigeharu, Emori Hisatoshi, Ashok C. Shah, Nishihata Toshiaki

Journal:

International Journal of Pharmaceutics

Année:

1994

Langue:

english

Fichier:

PDF, 594 KB

english, 1994

17

Application of model-independent and model analysis for the investigation of effect of drug solubility on its release rate from hydroxypropyl methylcellulose sustained release tablets

Koichiro Tahara, Ken Yamamoto, Toshiaki Nishihata

Journal:

International Journal of Pharmaceutics

Année:

1996

Langue:

english

Fichier:

PDF, 782 KB

english, 1996

18

Absorption-promoting adjuvants: enhancing action on rectal absorption

Toshiaki Nishihata, J.Howard Rytting

Journal:

Advanced Drug Delivery Reviews

Année:

1997

Langue:

english

Fichier:

PDF, 1.98 MB

english, 1997

19

Effects of Dithiothreitol and Ascorbate on the Penetration of Diclofenac Across Excised Rat Dorsal Skin

Toshiaki Nishihata, J. Howard Rytting, Koich Takahashi, Kiyoshi Sakai

Journal:

Pharmaceutical Research

Année:

1988

Fichier:

PDF, 474 KB

1988

20

New AlkylN,N-Dialkyl-Substituted Amino Acetates as Transdermal Penetration Enhancers

Ooi Wong, James Huntington, Toshiaki Nishihata, J. Howard Rytting

Journal:

Pharmaceutical Research

Année:

1989

Fichier:

PDF, 2.43 MB

1989

21

Possible Mechanism Regulating Barrier Function of Rat Intestinal Mucosa against Permeation of Cefmetazole, a Hydrophilic Drug

Toshiaki Nishihata, Hideo Takahata, Akira Kamada

Journal:

Pharmaceutical Research

Année:

1985

Fichier:

PDF, 571 KB

1985

22

Changes in Intestinal Mucosal Permeability Caused by Nonprotein Thiol Loss in Rats

Toshiaki Nishihata, Ba Thu Nghiem, Hironori Yoshitomi, Chian-Shun Lee, Margaret Dillsaver, Takeru Higuchi, Rifa Choh, Takumi Suzuka, Atsushi Furuya, Akira Kamada

Journal:

Pharmaceutical Research

Année:

1986

Fichier:

PDF, 1009 KB

1986

23

Ortho-hydroxybenzoates may act at the protein fraction to enhance membrane permeability

Toshiaki Nishihata, Takeru Higuchi

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

1984

Langue:

english

Fichier:

PDF, 240 KB

english, 1984

24

Induction of microvillous fusion and pinching-off by Concanavalin A

Toshiaki Nishihata, Paul R. Burton, Larry J. Caldwell

Journal:

Biochemical and Biophysical Research Communications

Année:

1986

Langue:

english

Fichier:

PDF, 2.41 MB

english, 1986

25

Possible mechanism of uptake for several compounds in ionized form through human erythrocyte membrane

Toshiaki Nishihata, Takeru Higuchi, Akira Kamada

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 841 KB

english, 1984

26

Salicylate-promoted permeation of cefoxitin, insulin and phenylalanine across red cell membrane. Possible mechanism.

Toshiaki Nishihata, Takeru Higuchi, Akira Kamada

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 390 KB

english, 1984

27

Promoting effect of concanavalin a on transport of sodium cefoxitin and phenol red from rat rectal compartment

Toshiaki Nishihata, Takeru Higuchi

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 598 KB

english, 1984

28

Inhibitory effect of salicylate on 2,4-dinitrophenol and diethyl maleate in isolated rat intestinal epithelial cells

Toshiaki Nishihata, Larry J. Caldwell, Kiyoshi Sakai

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

1988

Langue:

english

Fichier:

PDF, 784 KB

english, 1988

29

Prospective Validation of High-Shear Wet Granulation Process by Wet Granule Sieving Method. I. Selection and Characterization of Sieving Parameters for Wet Granules

Emori, Hisatoshi, Yoshizawa, Teruhisa, Nishihata, Toshiaki, Mayumi, Tadanori

Journal:

Drug Development and Industrial Pharmacy

Année:

1997

Langue:

english

Fichier:

PDF, 721 KB

english, 1997

30

Prospective Validation of High-Shear Wet Granulation Process by Wet Granule Sieving Method. II. Utility of Wet Granule Sieving Method

Emori, Hisatoshi, Sakuraba, Yoko, Takahashi, Koji, Nishihata, Toshiaki, Mayumi, Tadanori

Journal:

Drug Development and Industrial Pharmacy

Année:

1997

Langue:

english

Fichier:

PDF, 791 KB

english, 1997

31

Sustained-release of sodium diclofenac from suppository

Nishihata, Toshiaki, Wada, Hisayo, Kamada, Akira

Journal:

International Journal of Pharmaceutics

Année:

1985

Langue:

english

Fichier:

PDF, 563 KB

english, 1985

32

Investigation of sustained-release suppository of sodium diclofenac in humans

Nishihata, Toshiaki, Sudho, Masao, Kamada, Akira, Keigami, Masaharu, Fujimoto, Takashi, Kamide, Shigeo, Tatsumi, Nobuo

Journal:

International Journal of Pharmaceutics

Année:

1986

Langue:

english

Fichier:

PDF, 500 KB

english, 1986

33

Enhancement of rectal absorption of water-soluble antibiotics in dogs

Nishihata, Toshiaki, Rytting, J.Howard, Higuchi, Takeru, Caldwell, Larry J., Selk, Sally J.

Journal:

International Journal of Pharmaceutics

Année:

1984

Langue:

english

Fichier:

PDF, 846 KB

english, 1984

34

Effect of gelatin in the formulation on rectal insulin absorption in the presence of enamine in normal rats and depancreatized dogs

Suni, Kim, Toshiaki, Nishihata, Shoji, Kawabe, Yasufumi, Okamura, Akira, Kamada, Toshihito, Yagi, Ryuzo, Kawamori, Motoaki, Shichiri

Journal:

International Journal of Pharmaceutics

Année:

1984

Langue:

english

Fichier:

PDF, 602 KB

english, 1984

35

The effect of adjuvants on the colonie absorption of cefmetazole and [Asu1,7]-eel calcitonin in rats: concentration dependent absorption pathways

Nishihata, Toshiaki, Miyake, Masatoshi, Takahata, Hideo, Kamada, Akira

Journal:

International Journal of Pharmaceutics

Année:

1986

Langue:

english

Fichier:

PDF, 777 KB

english, 1986

36

Effect of pH on the dissolution of drug particle dispersed in solid matrix of hydrogenated soya phospholipid

Takahashi, Koichi, Katagi, Toyoshi, Tamagawa, Satoko, Nishihata, Toshiaki

Journal:

International Journal of Pharmaceutics

Année:

1989

Langue:

english

Fichier:

PDF, 271 KB

english, 1989

37

Percutaneous absorption of diclofenac in rats and humans: aqueous gel formulation

Toshiaki, Nishihata, Akira, Kamada, Kiyoshi, Sakai, Koichi, Takahashi, Koichi, Matsumoto, Kazuhiko, Shinozaki, Yujin, Tabata, Masaharu, Keigami, Tateo, Miyagi, Nobuo, Tatsumi

Journal:

International Journal of Pharmaceutics

Année:

1988

Langue:

english

Fichier:

PDF, 541 KB

english, 1988

38

Rectal absorption and lymphatic uptake of Ara-C in rats

Nishihata, Toshiaki, Kim, Suni, Liversidge, Gary G., Higuchi, Takeru

Journal:

International Journal of Pharmaceutics

Année:

1986

Langue:

english

Fichier:

PDF, 677 KB

english, 1986

39

Preliminary study on sustained-release particles prepared with hydrogenated soya phospholipid and cholesterol

Nishihata, Toshiaki, Hirotani, Yoshihiko, Yamazi, Akira, Takahashi, Kohichi, Yoshitomi, Hironori

Journal:

International Journal of Pharmaceutics

Année:

1988

Langue:

english

Fichier:

PDF, 362 KB

english, 1988

40

Simple formulation of sustained-release tablets of sodium diclofenac and examination in humans

Nishihata, Toshiaki

Journal:

International Journal of Pharmaceutics

Année:

1987

Langue:

english

Fichier:

PDF, 332 KB

english, 1987

41

Trials of rectal insulin suppositories in healthy humans

Toshiaki, Nishihata, Yasufumi, Okamura, Hideki, Inagaki, Masao, Sudho, Akira, Kamada, Toshihito, Yagi, Ryuzo, Kawamori, Motoaki, Shichiri

Journal:

International Journal of Pharmaceutics

Année:

1986

Langue:

english

Fichier:

PDF, 387 KB

english, 1986

42

Clinical investigation of sodium diclofenac sustained-release suppositories

Nishihata, Toshiaki, Keigami, Masaru, Kamada, Akira, Fujimoto, Takashi, Kamide, Shigeo, Tatsumi, Nobuo

Journal:

International Journal of Pharmaceutics

Année:

1988

Langue:

english

Fichier:

PDF, 465 KB

english, 1988

43

Griseofulvin-Hydrogenated Soya Phospholipid Coprecipitates

Nishihata, Toshiaki, Chigawa, Yoshiko, Kamada, Akira, Sakai, Kiyoshi, Mastumoto, Koichi, Shinozaki, Kazuhoko, Tabata, Yujin

Journal:

Drug Development and Industrial Pharmacy

Année:

1988

Langue:

english

Fichier:

PDF, 646 KB

english, 1988

44

Sustained Release Suppository of Sodium Diclofenac: use of Water Absorbable Polymer

Nishihata, Toshiaki, Tsutsumi, Ayumi, Ikawa, Chie, Sakai, Kiyoshi

Journal:

Drug Development and Industrial Pharmacy

Année:

1990

Langue:

english

Fichier:

PDF, 390 KB

english, 1990

45

Effects of Particle Size of Bulk Drug and food on the Bioavailability of U-78875 in Dogs

Nishihata, Toshiaki, Ishizaka, Mayumi, Yokohama, Sigeharu, Martino, Alice C., Gordon, Roger E.

Journal:

Drug Development and Industrial Pharmacy

Année:

1993

Langue:

english

Fichier:

PDF, 822 KB

english, 1993

46

Aqueous-Lipid Transdermal Formulation of Anti-Inflammatory Agents, Prepared with Hydrogenated Soya Phospholipid

Nishihata, Toshiaki, Rytting, J. Howard, Tsutsumi, Ayumi, Sakai, Kiyoshi

Journal:

Drug Development and Industrial Pharmacy

Année:

1991

Langue:

english

Fichier:

PDF, 570 KB

english, 1991

47

Effect of Dissolution Rate and Food on Oral Bioavailability of Bropirimine Tablets in Dogs

Emori, Hisatoshi, Yamamoto, Ken, Nishihata, Toshiaki

Journal:

Drug Development and Industrial Pharmacy

Année:

1996

Langue:

english

Fichier:

PDF, 511 KB

english, 1996

48

Compatibility of U-67590A Sterile Solution with Normal Saline, Dextrose Solution, and Solita-T No. 3 with or without Aminophylline Injectable

Okamoto, Hirokazu, Mori, Kiyoko, Nishihata, And Toshiaki

Journal:

Drug Development and Industrial Pharmacy

Année:

1994

Langue:

english

Fichier:

PDF, 680 KB

english, 1994

49

Evaluation of Enteric Coated Tablet Sensitive to Pancreatic Lipase. II. In vivo Evaluation.

YOSHITOMI, Hironori, SHIZUKU, Yoshihiro, MASUDA, Yasuko, ITAKURA, Rie, OKAMOTO, Satoko, TOMIDA, Hisao, NISHIHATA, Toshiaki, GOTO, Shigeru

Journal:

Biological & Pharmaceutical Bulletin

Année:

1993

Fichier:

PDF, 706 KB

1993

50

Inhibitory Effect of Clindamycin on Production of .BETA.-Lactamase in .BETA.-Lactam-Resistant Bacteria.

NISHIHATA, Toshiaki, KUNIEDA, Sachiyo, NAKAHAMA, Chikara, SOEJIMA, Rinzo

Journal:

Biological & Pharmaceutical Bulletin

Année:

1994

Fichier:

PDF, 968 KB

1994